Nitric oxide from vascular smooth muscle cells: regulation of platelet reactivity and smooth muscle cell guanylate cyclase
نویسندگان
چکیده
منابع مشابه
Vascular smooth muscle and nitric oxide synthase.
The concept of endothelium-derived relaxing factor (EDRF) put forward in 1980 by Furchgott and Zawadzki implies that nitric oxide (NO) produced by NO synthase (NOS) in the endothelium diffuses to the underlying vascular smooth muscle, where it modulates vascular tone as well as vascular smooth muscle cell (VSMC) proliferation by increasing cGMP formation with subsequent activation of cGMP-depen...
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THE CURRENT ARTICLE IN FOCUS by Mingone and colleagues (Ref. 16, see p. L296 in this issue) describes a novel permissive effect of hypoxia on cGMP-independent relaxation to nitric oxide (NO) in bovine pulmonary and coronary arteries. Interestingly, whereas NO-mediated vasorelaxation appeared to be largely a function of cGMP at ambient PO2, a cGMP-independent mechanism involving activation of th...
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1. Introduction with thiol groups to produce nitrosothiols [9]. Hence, the effects of NO and the pathophysiological influences on it Vascular smooth muscle cell (VSMC) proliferation is an may also be mediated indirectly, potentiated or inhibited important component of vessel wall remodelling in re-through the availability of these oxygen species. Irre-sponse to injury, for example, after angiop...
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Recent demonstration of cytokine-inducible production of nitric oxide (NO) in vascular smooth muscle cells (VSMC) from rat aorta has implicated VSMC-derived NO as a key mediator of hypotension in septic shock. Our studies to determine whether an inducible NO pathway exists in human VSMC have revealed a novel cytokine-inducible, NO-independent pathway of guanylate cyclase activation in VSMC from...
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We investigated the effects of troglitazone on cytokine-stimulated nitric oxide (NO) production in cultured rat vascular smooth muscle cells (VSMC). The increase in NO formation caused by interleukin-1alpha (IL-1) was enhanced by troglitazone in a concentration-dependent manner. Bacterial lipopolysaccharide-stimulated NO synthesis was also increased by troglitazone. The combinations of IL-1, tu...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1991
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1991.tb12481.x